Cabazitaxel
High-quality chemical supplied by Jinan Shenghe Chemical Co., Ltd. Competitive pricing, reliable delivery, and full technical support for B2B buyers worldwide.
Specifications
| Molecular Formula | C45H57NO14 |
|---|---|
| Molecular Weight | 835.95434 |
Detailed Chemical Properties & Synonyms
Opis
Cabazitaxel · CAS 183133-96-2 · C45H57NO14. UNII 51F690397J. Temperatura topnienia: 170.
Identyfikacja
| Numer rejestracyjny CAS | 183133-96-2 |
|---|---|
| PubChem CID | 9854073 |
| Wzór cząsteczkowy | C45H57NO14 |
| Nazwa IUPAC | [(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-acetyloxy-1-hydroxy-15-[(2R,3S)-2-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]oxy-9,12-dimethoxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate |
| UNII (FDA) | 51F690397J |
Obliczone deskryptory
| Masa cząsteczkowa | 835.9 |
|---|---|
| XLogP3 | 2.7 |
| Liczba donorów wiązań wodorowych | 3 |
| Liczba akceptorów wiązań wodorowych | 14 |
| Liczba wiązań rotowalnych | 15 |
| Masa dokładna | 835.37790549 |
| Masa monojzotopowa | 835.37790549 |
| Topologiczne polarne pole powierzchni | 202 |
| Liczba atomów ciężkich | 60 |
| Ładunek formalny | 0 |
Właściwości fizyczne & chemiczne
| Temperatura topnienia | 170 |
|---|
Opis fizyczny & wskazówki dotyczące obchodzenia się
- Solid
Klasyfikacja zagrożeń GHS
| Zgłoszone zwroty wskazujące rodzaj zagrożenia | H302 (85.7%), H311 (42.9%), H315 (85.7%), H317 (14.3%), H318 (14.3%), H335 (14.3%), H341 (85.7%), H360 (57.1%) |
|---|
H302 (85.7%): Działa szkodliwie po połknięciu [Uwaga Toksyczność ostra, doustna]
H311 (42.9%): Działa toksycznie w kontakcie ze skórą [Niebezpieczeństwo Toksyczność ostra, skórna]
Udokumentowane zastosowania
- Cabazitaxel is indicated, in combination with [prednisone], for the treatment of patients with metastatic castration-resistant prostate cancer previously treated with a [docetaxel]-containing treatment regimen. In Europe and Canada, it can also be used in combination with [prednisolone].
- Cabazitaxel is a taxane and antineoplastic agent which is currently used in the therapy of castration-resistant metastatic prostate cancer after failure of docetaxel. Therapy with cabazitaxel has been associated with a low rate of serum enzyme elevations, but has not been linked to cases of clinically apparent acute liver injury, although it can cause severe hypersensitivity infusion reactions which in some instances can be associated with acute liver injury.
- Cabazitaxel is approved to be used with prednisone to treat:
- • Prostate cancer that has metastasized (spread to other parts of the body) in men whose cancer is castrate resistant (has not responded to treatments that lower testosterone levels) and who have already been treated with chemotherapy that included docetaxel.
- Cabazitaxel is also being studied in the treatment of other types of cancer.
- Avoid grapefruit products. Grapefruit inhibits the CYP3A4 metabolism of cabazitaxel, which may increase its serum concentration.
Synonimy
CABAZITAXEL; 183133-96-2; Jevtana; Taxoid XRP6258; Xrp6258; Cabazitaxelum; TXD 258; XRP-6258; Jevtana Kit; TXD258; Cabazitaxel Injection; XRP 6258; kabazitaxel; NSC-761432; TXD-258; 51F690397J
Często zadawane pytania
Jaki jest numer CAS i wzór cząsteczkowy Cabazitaxel?
CAS 183133-96-2; wzór cząsteczkowy C45H57NO14; masa cząsteczkowa — g/mol.
Pod jakimi innymi nazwami znany jest Cabazitaxel?
CABAZITAXEL, 183133-96-2, Jevtana, Taxoid XRP6258, Xrp6258, Cabazitaxelum.
Czy Cabazitaxel jest klasyfikowany jako niebezpieczny?
Zgłoszone zwroty zagrożenia: H302, H311, H315, H317, H318.
Jakie są kluczowe właściwości fizyczne Cabazitaxel?
Temperatura topnienia: 170.
Dane na tej stronie pochodzą z PubChem (US National Library of Medicine) i Wikidata. Dane specyficzne dla gatunku — zawartość, wilgotność, wielkość cząstek, opakowanie, okres przydatności — są wydawane dla każdej partii w COA i nie są tu publikowane.
Packaging & Shipping
- Standard: 25 kg fiber drum / 200 kg steel drum with double PE liner
- Small pack: 1 kg / 5 kg aluminum foil bag for lab & sample
- Custom: packaging size and labeling per customer requirement
- Lead time: in-stock items ship within 3-5 business days
- Documents: COA, MSDS / SDS, TDS provided with every shipment
- Global: air, sea (FCL / LCL) and express to 80+ countries
Storage & Handling
Store in a cool, dry, well-ventilated place away from heat, direct sunlight and incompatible materials. Keep container tightly closed. Use appropriate personal protective equipment and refer to the SDS for full safety guidance before handling.
Frequently Asked Questions
Yes. A batch-specific COA and free or charged sample are available on request before bulk ordering.
Yes. We offer custom grade, particle size and purity adjustment based on your application and order volume.
MOQ depends on the product; small quantities are supported for R&D and trial runs.
Every batch is tested in-house and retains full traceability from raw material to finished goods.
Why Choose Jinan Shenghe Chemical
Request a Quote
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About Jinan Shenghe Chemical Co., Ltd.
Jinan Shenghe Chemical Co., Ltd.
We are a professional chemical supplier based in Jinan, China. Since 2013, we have been connecting manufacturers and global B2B buyers with reliable sourcing, quality-controlled products and efficient logistics.
Our business covers food & feed additives, fine chemicals, pharmaceutical intermediates, eco-materials, coatings and specialty chemicals — all non-hazardous and compliant with our licensed scope.